组织工程补片治疗尿道下裂修补后尿漏(英文)

Tissue engineered patch treatment of the urinary leakage after hypospadias repair

背景：以往尿道下裂手术多选用自身组织进行修补,但Ⅰ期术后尿漏患者再次手术修补时局部可用组织较少,且应用其他组织存在操作复杂、损伤大等危险。目的：观察组织工程补片治疗尿道下裂的效果,评价其组织相容性情况及临床疗效。方法：2009-01/2010-10 对 8 例尿道下裂手术后尿漏患者行组织补片Ⅰ期尿道成型术,观察修补后疗效及围手术期的组织相容性。结果与结论：8 例患者均Ⅰ期手术成功,其中 1 例出现轻度漏尿、给予局部涂抹生物蛋白胶后漏尿现象消失,住院期间无发热、局部水肿、皮管及皮瓣坏死等情况,随访 4~6个月,患者可以站立排尿,未出现漏尿、顽固性包皮水肿等并发症。

BACKGROUND： The hypospadias is usually repaired by the autologous tissues by surgery, but there is few local tissues available in patients with urinary leakage after I stage surgical repair, while other tissues require complex operations and induces large injury. OBJECTIVE： To observe the tissue engineered patches in the treatment of hypospadias, and to evaluate the biocompatibility and clinical efficacy. METHODS： Eight patients with urinary leakage after surgery for hypospadias repair underwent tissue patch I stage urethroplasty from January 2009 to October 2010. The curative effect and perioperative histocompatibility were determined. RESULTS AND CONCLUSION： Eight patients were uniformly successful after I stage surgery. One out of the 8 patients appeared mild urinary leakage and well cured by topical fibrin glue. There was no fever, local edema, skin tube and flap necrosis occurred during the postoperative hospital stay. All patients were followed up for 4-6 months, patients were observed to urinate standing, without urinary leakage, refractory prepuce edema and other complications.