中国胰岛移植治疗1型糖尿病临床与研究现状(英文)

Clinical and research status of islet transplantation for type 1 diabetes in China

背景:胰岛移植是治疗胰岛素敏感的 1 型糖尿病患者的有效方法。目的:调查与评估中国胰岛移植治疗 1 型糖尿病的现状及面临的困境。方法:从中国当代医学期刊目录数据库中检索并分析 1980-01/2008-12 发表的有关胰岛移植的文章,解析国家自然科学基金数据库中2002/2008有关胰岛移植的课题资助数据,评估国内胰岛移植的临床及基础研究现状。结果与结论:共检索到有关胰岛移植的文章340 篇,包括基础研究 165 篇(48.5%),临床研究 45 篇(13.2%),综述性文献 130 篇(38.2%)。绝大多数研究是经济发达地区完成的,爱得蒙顿方案对中国胰岛移植的发展产生巨大影响,近年来越来越多的胰岛移植课题得到国家自然科学基金的资助。然而,中国胰岛移植的发展依然面临供体缺乏、器官捐献系统尚未完善、资金短缺等困难。

BACKGROUND： Islet transplantation is an effective therapy for type I diabetic patients sensitive to insulin. OBJECTIVE： To investigate and evaluate the status and obstacles of islet transplantation in type I diabetes in China. METHODS： Published articles reported from January 1980 to December 2008 on Chinese Medical Current Contents database, the national funds from 2002 to 2008 in the database of National Natural Science Foundation of China on islet transplantation were searched to analyze the status of islet transplant research and clinical practice in China. RESULTS AND CONCLUSION： 340 articles were reported from 1980 to 2008 related to islet transplantation in China, including 165 （48.5%） basic research, 45 （13.2%） clinical research and 130 （38.2%） reviews. Most of researches were conducted in the developed regions in the east of China. The Edmonton protocol had a great impact on the islet transplant research in China, and many projects of islet transplant have been supported by the National Natural Science Foundation. However, there remains obstacles in this field, such as organ and capital shortage and incomplete organ donation system.