质子泵抑制剂长期使用安全性评价

Evaluate Safly of Pump Inhibitors for long term use

质子泵抑制剂长期使用使肺炎、腹泻和骨折发生的风险增加．并且与氯毗格雷合用可以增加心血管事件的风险，应严格按照质子泵抑制剂的适应证用药．加强长期用药的随访和监护。本文旨在对质子泵抑制剂长期使用的安全性情况进行评价。

Proton pump inhibitors longterm use increases risk of Pneumonia, diarrhea and fracture, and also can increase risk of Cardiovascular disease to combine with clopidogrel. We should control proton pump inhibitors indications of use strictly, and strengthen follow-up and monitoring for long-term medicating. Safty situation of proton pump inhibitors for long-term use was Evaluated.