乙肝肝硬化患者的抗病毒治疗

Antiviral Therapy in Patients with Hepatitis B Virus-induced Cirrhosis

乙肝肝硬化是HBV感染的最终结局之一。目前的研究证明,抗病毒治疗能使肝脏组织学获得改善甚至逆转肝硬化的病情。多种核苷(酸)类似物及干扰素的临床应用,使乙肝肝硬化的抗病毒治疗取得较大进展,但患者仍需长期甚至终生治疗。因此,应遵循个体化的治疗原则,针对患者病情、药物特点、不良反应、患者经济承受能力,选择强效、低耐药且较经济的治疗方案以获得最佳疗效。

fLiver cirrhosis is one of the final outcomes of hepatitis g infection. Studies have demonstrated that anti--HBV therapy, including interferon and nucleosides/nucleotides analogues, can lead to histological improvement, and even corn plete reversibility of liver cirrhosis, a long--term or even life--long treatment is needed. Therefore, the treatment of hepatitis B virus--induced cirrhosis should be abided by individual therapeutic principles, according to the patient＇s condition, drug characters/side effects and cost--effectiveness. More effective, safe and affordable anti--HBV agents are needed for these populations.