血压正常的超重和肥胖人群的肾功变化

Change of Renal Function in Overweight and Obesity People with Normal Blood Pressure

为了探讨健康体检中血压正常的超重和肥胖人群的肾功有无变化。对3 756例体检者测量身高、体重、血压,检测各项生化指标,计算肾小球滤过率(GFR)、体质指数(BMI)。结果显示:男性的eGFR较女性低。年龄与eGFR相关性强。消除了性别和年龄的影响后,分析表明随着体质指数的升高,eGFR逐渐降低,而肌酐却无差异。我们发现血压正常的超重和肥胖人群体检虽肌酐正常,但eGFR却明显下降,表明存在肾功损害,故我们需早期识别,定期复诊,防止肥胖相关性肾病发生。

To explore the change of renal function in overweight and obesity people with normal blood pressure, 3756 health subjects were enrolled in this study. Measure body length, body weight and blood pressure, detect biochemical parameters and calculate eGFR and BMI. Results showed the eGFR was lower in male than female subjects; and age had the highest r value; after adjusting sex and age with covariance analysis, eGFR was declined gradually with the increase in BMI, but serum creatinine had not significantly difference. Therefore overweight and obesity people may have renal function damage even if they have normal blood pressure.