比阿培南治疗肝衰竭并发细菌感染疗效观察

Study on the clinical efficacy of biapenem in treatment of hepatic failure complicated with bacterial infection

目的观察比阿培南治疗肝衰竭并发细菌感染的临床疗效。方法30例肝衰竭并发细菌感染患者随机分成两组，分别给予比阿培南（观察组）、头孢哌酮／他唑巴坦钠（对照组）治疗，治疗1周后比较两组疗效。结果观察组有效率86．67％、治愈率73．33％，优于对照组（53．33％、33．33％，均P〈0．05）。结论比阿培南治疗肝衰竭并发细菌感染疗效确切，不良反应轻微。

Objective To explore the clinical efficacy of biapenem treatment of in hepatic failure complicated with bacterial infection. Methods 30 patients with hepatic failure complicated with bacterial infection were randomly divided into two groups. Treatment group were administered biapenem （ Zhengda Tianqing Pharmaceuticals） 0. 6g/d,while the control group were administered cefopergone sodium tazobactam sodium for Injection（ Qili Haikou Pharmaceuticals） 4.0g/d for one week. Results There were signitican differences in the curative rate and effective rate of biapenem and cefopergone sodium tazobactam sodium,which were 86.67% 73.33% and 53.33% ,33. 33% respeitively（P 〈 0.05）. Conclusion Biapenem in treatment of hepatic failure complicated with bacterial infections was effective against infection with mild adverse reactions.