干扰素联合更昔洛韦治疗传染性单核细胞增多症

Effect of interferon combined with gancidovir in treatment of children infectious mononucleosis related to EB virus

目的探讨干扰素联合更昔洛韦治疗儿童EB病毒相关传染性单核细胞增多症（IM）的临床疗效。方法45例EB病毒相关IM患儿在知情同意下随机分为观察组25例和对照组20例，两组均采用常规治疗及干扰素治疗，观察组在此基础上加用更昔洛韦，连用5—7d。观察比较两组临床症状转归及临床疗效等。结果观察组患儿住院、恢复正常体温、淋巴结缩小、脾脏回缩、肝脏回缩、咽峡炎缓解和异淋恢复的时间[（10．2±3．6）d、（3．2±1．4）d、（6．7±2．2）d、（10．2±3．3）d、（8．3±2．7）d、（8．2±3．4）d、（9．4±3．2）d]均明显短于对照组[（13．4±3．9）d、（5．6±2．3）d、（11．2±2．8）d、（12．1±3．2）d、（10．0±1．8）d、（11．1±3．8）d、（12．1±3．5）d]（均P〈0．05）；观察组患儿的治疗有效率达96％，明显高于对照组80％（P〈0．05）。结论更昔洛韦联合干扰素对儿童EB病毒相关传染性单核细胞增多症能够提高有效率。

Objective To discuss the clinical effects of interferon combined with ganciclovir in treating children infectious mononucleosis（IM） related to EB virus. Methods 45 IM cases were distributed into study group with 25 cases and control group with 20 cases based on parents known and agreed. Children of two groups were both treated with traditional treatment and interferon, and children in study group were added treatment with ganciclovir. To separately observe the improvement and clinical effects of two groups. Results The time of hospital stay, normal body temperature returned, lymph nodes reduced, spleen retraction, liver retraction, angina relieve and abnormal lymphatic recovery of study group[ （10.2 ±3.6）d,（3.2 ± 1.4）d,（6.7 ±2.2）d, （10.2 ±3.3）d,（8.3 ±2.7）d, （8.2 23.4） d, （ 9.4 ± 3.2） d, were significantly less than control group （ 13.4 ± 3.9 ） d, （ 5.6 ± 2.3 ） d, （ 11.2 ± 2.8 ） d, （ 12.1 ± 3.2）d,（10.0±1.8）d,（11. 1 ±3.8）d,（12.1 ±3.5）d],（allP〈0.05 ）. The effective rate of study group 96% was significantly higher than control group 80% （ P 〈 0. 05 ）. Conclusion It had good effects of interferon combined with ganeielovir in treating children infectious mononucleosis related to EB virus, which could improve the clinical effective rate and less the duration of adverse symptoms.