玫瑰花糖膏对大鼠胃肠激素的影响

Effect of Qizil Guliqent on gastrointestinal hormone in rats

目的 观察玫瑰花糖膏对大鼠胃肠激素水平的影响.方法 选用Wistar大鼠50只,随机分为空白对照组（0.5％羧甲基纤维素钠）、多潘立酮组（0.0027 g/kg）、玫瑰花糖膏组（4 g/kg、6 g/ks、8 g/kg）,连续灌胃给药20d,用酶联免疫分析测定大鼠血清胃动素（MTL）、血管活性肠肽（VIP）、胃泌素（GAS）水平.结果 与空白对照组比较,玫瑰花糖膏（4 g/kg、6 g/ks）能升高血清VIP水平（P＜0.05～P＜0.01）,对MTL、GAS水平的影响无统计学意义（P＞0.05）.与空白对照组比较,多潘立酮组、玫瑰花糖膏组（8g/ks）能升高血清MTL、GAS水平（P＜0.05）,对VIP水平的影响无统计学意义（P＞0.05）.结论 玫瑰花糖膏对胃肠激素有一定的调节作用,其作用与剂量有关.

Objective To investigate the effect of Qizil guliqent on gastrointestinal hormone in normal rats.Methods The rats in experimental groups were administered with Qizil guliqent（4g/kg,6g/kg,8g/kg ）,madinglin （0.0027g/kg）,and the rats in normal control group were given 0.5% CMC-Na for twenty days.The method ELISA was used to detect the content of gastric motility（MTL）,vasoactive intestinal peptide（VIP） and Gastrin（GAS） in serum of normal rats.Results In comparison with normal control group,VIP increased in Qizil guliqent group（4g/kg,6g/kg） （P 〈0.05 ～P 〈 0.01 ）;but MTL,GAS were not significantly changed in this group（ P 〉 0.05 ）.MTL,GAS were increased in Qizil guliqent group （ 8g/kg ） and madinglin group （0.0027g/kg） （ P 〈 0.05 ） ; but VIP was not significantiy changed in this group（P 〉 0.05 ）.Conclusion Qizil guliqent could regulate gastrointestinal hormones in rats,and dose related.