血浆氨基肽酶A水平与原发性高血压相关性分析

Study on the correlation between plasma aminoPePtidase A and essential hypertension

目的 探讨高血压人群血浆氨基肽酶A（APA）与原发性高血压的相关性.方法 对淮南市汉族人群进行问卷调查和血压、身高、体质量的测量,征集到高血压家系的高血压患者与血压正常者分别为131例与134例、非高血压家系的高血压患者与血压正常者分别为127例与132例为研究对象.分别应用RIA法和ELISA法测定研究对象的血浆血管紧张素Ⅱ（AngⅡ）与APA水平.结果 两个家系中高血压组AngⅡ与APA水平显著高于非高血压组（t=10.3398,6.5613,11.7089,6.6683,均P＜0.01）.且高血压家系高血压组AngⅡ与APA水平显著高于非高血压家系的高血压组（t=3.6201,6.1091,均P＜0.01）.平均动脉血压与两个家系中高血压组AngⅡ水平与APA水平均呈显著正相关（非高血压家系r=0.315,0.392,均P＜0.05,高血压家系r=0.412,0.505,均P＜0.01）.高血压家系中高血压组血浆AngⅡ水平与APA水平呈正相关（r=0.322,P＜0.05）.结论 血浆APA水平在不同家系存在差异；高血压家系的高血压人群血浆APA水平显著升高,并与血压有一定的相关性.

Objective To study the correlation between essential hypertension and plasma aminopeptidase A.Methods The people of the Han nationality in Huainan city received questionnaire investigation and their blood pressure,height and weight were measured.131 individuals suffered from hypertension and 134 healthy individuals belongs to hypertensive pedigree and 127 individuals suffered from hypertension and 132 healthy individuals belongs to non-hypertensive pedigree were reseached.The level of Ang Ⅱ in plasma was detected by RIA,and the level of APA was detected by ELISA.Results The levels of Ang Ⅱ and APA in plasma in HP group was significantly higher than that in NHP group in two pedigrees （ t =10.3398,6.5613,11.7089,6.6683,all P 〈 0.01 ）.Furthermore,the levels of Ang Ⅱ and APA in plasma in HP group in hypertensive pedigree was significantly higher than that in HP group in nonhypertensive pedigree（t =3.6201,6.1091,all P 〈 0.01 ）.There was significantly positive correlation between MAP and the levels of Ang Ⅱ and APA in plasma in HP group in two pedigrees （ r =0.315,0.392,all P 〈 0.05 in non-hypertensive pedigree,and r =0.412,0.505,all P 〈 0.01 in hypertensive pedigree ）.There was positive correlation between the levels of Ang Ⅱ and APA in plasma in HP group in hypertensive pedigree （ r =0.322,P 〈 0.05 ）.Conclusion There was significant difference between hypertensive pedigree and non-hypertensive pedigree in the levels of APA;The levels of APA in plasma in HP group was significantly increased in the individuals suffered from hypertension,and was positively correlated with MAP.