松龄血脉康联合氯沙坦治疗女性更年期高血压

Clinical observation on Songlingxuemaikang combined with losartan in treatment of female menopausal hypertension

目的 探讨松龄血脉康联合氯沙坦对女性更年期高血压患者血压和生活质量的影响.方法 将87例女性更年期高血压患者随机分为联合组（松林血脉康联合氯沙坦钾）44例和对照组（单用氯沙坦钾）43例,分别于治疗前后进行24h动态血压监测（ABMP）、血脂及相关临床症状的观察.结果 治疗2个月后,联合组可明显降低血压变异性和夜间血压下降率,且优于对照组（均P＜0.05）；治疗组降压总有效率和显效率分别为90.9％、63.6％,均优于对照组的74.4％、39.5％（x2=4.15,5.06,均P＜0.05）.同时能有效的改善临床症状,在降低总胆固醇（TC）、低密度脂蛋白（ LDL-C）方面明显优于对照组（均P＜0.01）.结论 松龄血脉康联合氯沙坦钾治疗更年期女性高血压患者具有较好的降压作用,能降低更年期女性高血压变异性,并能改善更年期综合征症状、血脂代谢,提高女性更年期高血压患者的生活质量.

Objective To explore the effect of Songlingxuemaikang combined with losartan on the blood pressure and quality of life in female patients with menopausal hypertension.Methods 87 female patients with menopausal hypertension were randomly divided into combined group （Songlingxuemaikang combined with losartan group,44 cases） and the control group（losartan alone,43 cases）.Before and after treatment the ambulatory blood pressure （ABMP） was monitored for 24h,and blood lipids and clinical symptoms were observed.Results After two months treatment,the blood pressure variability and nighttime blood pressure decrease rate of the combination group significantly reduced,and better than those of the control group（ all P 〈0.05） ;The effective rate and efficiency rate of the combination group were 90.9%,63.6% respectively,and was higher than 74.4%,39.5% in the control group（ x2 =4.15,5.06,all P 〈 0.05 ）.The clinical symptoms improving,total cholesterol （ TC ） reducing,density lipoprotein （LDL-C） lowing in the combination group was superior to the control group（ all P 〈 0.05）.Conclusion Songlingxuemaikang combined with losartan in treatment of female patients with menopausal hypertension had a good antihypertensive effect,and could reduce blood pressure variability in menopausal women,improve the symptoms of menopause and lipid metabolism,incresse the quality of lfie of patients with menopausal hypertensive.