河北省肿瘤高、低发地区饮水中“三氮”含量与食管癌发病相关性研究

Correlation between esophageal cancer and nitrogen compounds in drinking water

目的对比邯郸市涉县与张家口市赤城县上消化道肿瘤高、低发区食管癌发病及饮水中"三氮"含量情况;探寻饮水中"三氮"含量与食管癌发病的关系,为食管癌高发区病因学及一级预防提供线索。方法回顾性调查上消化道肿瘤高发区涉县及低发区赤城县1990～2009年食管癌发病率;分别检测两县三乡饮水中硝酸盐、亚硝酸盐、氨氮含量。结果涉县、赤城县1990～1999年与2000～2009年食管癌发病率差异无统计学意义(P>0.05),但涉县与赤城县发病率差异有统计学意义(P<0.01);涉县、赤城县饮水中硝酸盐、氨氮含量差异有统计学意义(P<0.01),而亚硝酸盐含量差异无统计学意义(P>0.05);相关性分析显示,饮水中硝酸盐、氨氮含量与食管癌发病率呈正相关,亚硝酸盐与食管癌发病率无明显相关。结论饮水中硝酸盐、氨氮可能是高发区食管癌发病的重要病因。

Objective To explore the correlation of esophageal cancer and nitrogen compounds in drinking water in high and low incidence areas. Methods Survey was conducted on the incidence of esophageal cancer in the areas with high （Shexian county） and low （Chicheng county） incidence in 1990-2009,the level of nitrate, nitrite and ammonia in drinking water were determined. Results Between high- and low-incidence areas in 1990-1999 and 2000-2009, there were very significant difference of esophageal incidence （ P d0.01）, the nitrate and the ammonia level of high-incidence area were higher than those of low-incidence area, too （ P d0.01）, but the nitrite level had not significant difference（ P〉0.05）. Correlation analysis showed that nitrate and ammonia level were correlated with the incidence of esophageal cancer （ r =0. 592, P〈0.01, r = 0. 394, P〈0.01）. Conclusion Nitrate and ammonia may be important factors of esophageal cancer.