摘要
目的探讨慢性心力衰竭(以下简称心衰)患者血清肿瘤相关糖类抗原125(CA125)和脑钠肽(BNP)水平变化及其意义。方法按AHA心衰指南标准随机入选113例慢性心衰患者,按照NYHA心功能分级将其分为两组,A组:NYHA 2级55例,B组:NYHA 3～4级58例。CA125和BNP的测定:采用化学发光技术分别测定所有患者入院第2天CA125和BNP水平。对B组患者出院前复测CA125和BNP水平。结果 NYHA 3～4级组与NYHA 2级组比较,CA125和BNP水平显著升高(〔95±86)U/ml vs(20±26)U/ml(,1052±959)pg/ml vs(317±513)pg/ml,P<0.01〕,经标准心衰治疗后CA125和BNP水平明显下降(〔95±86)U/ml vs(30±21)U/ml(,1052±959)pg/ml vs(351±213)pg/ml,P<0.01〕。结论和BNP一样,CA125也是诊断和评价慢性心衰的一个良好指标。
Objective We assessed the correlation of plasma carbohydrate antigen125（CA125）and plasma B-type natriuretic peptide（BNP） levels with the severity of congestive heart failure（CHF） and investigated their significance in assessment the severity of heart failure. Methods The patients were divided into two groups,according to their New York Heart Association（NYHA）functional class.Group A contained 55 patients with NYHA class 2.Group B contained 58 patients with NYHA class 3-4.Plasma levels of CA125 and BNP were tested in all patients on the second day after admission and the day before discharge in patients in group B.Results Serum levels of CA125 and BNP were higher in groups B than those in group A（（95±86） U/ml vs（20±26）U/ml,（1052±959）pg/ml vs（317±513） pg/ml respectively,P0.01）.The levels of CA125 and BNP decreased after effective treatments（（95±86） U/ml vs（30±21）ml,（1052±959）pg/ml vs（351±213）Pg/ml respectively,P0.01）.Conclusion Serum levels of CA125 and BNP are associated with the severity of CHF.We therefore conclude that CA125 can be used as a diagnostic and prognostic marker of CHF severity as well as BNP.
出处
《临床医学》
CAS
2011年第9期11-12,共2页
Clinical Medicine
