MRI引导下立体定向活组织检查诊断中枢神经系统淋巴瘤

Diagnosis of Central nervous system lymphoma by MRI-guided stereotactic biopsy

目的:探讨MRI引导下立体定向活组织检查(活检)手术在中枢神经系统淋巴瘤诊断中的应用,提高中枢神经系统淋巴瘤的诊断水平。方法:对16例疑诊中枢神经系统淋巴瘤的患者行MRI引导下立体定向活检手术。安装Leksell立体定向头架,行MRI扫描,计算靶点取标本,所取标本送病理学检查。结果:16例患者手术成功率100%,经病理证实,均诊断为中枢神经系统淋巴瘤,其中15例为弥漫性大B细胞淋巴瘤,1例为Burkitt淋巴瘤。术后复查CT有4例出现血肿,1例患者于术后第4日出现迟发性出血、脑疝,行开颅手术后死亡。结论:立体定向活检术对于明确诊断中枢神经系统淋巴瘤,具有重要的应用价值。

Objective： To evaluate the accuracy and complications of MRI-guided frame-based stereotactic brain biopsy procedures in the diagnosis of Central nervous system CNS lymphoma. Methods： MRI-guided stereotactic brain biopsy was performed in 16 suspected patients with （CNS） lymphoma. Anatomical location, diagnostic accuracy, morbidity and mortality were analyzed. Results： A total of 16 Stereotactic surgery procedures were successfully performed. All were pathologically proven CNS lymphoma, with 15 cases of diffuse large B-cell lymphoma and 1 case of Burkitt lymphoma. Diagnostic accuracy was 100% in this study. Hemorrhage was detected in 4 cases using postoperative CT Scanning. One patient died of delayed intracranial hematoma. Conclusion： MRI- guided stereotactic brain biopsy is a reliable and safe method for the diagnosis of CNS lymphoma.