恶性肿瘤稳定期与转移期血小板变化

Changes of platelets in cancer patients with tumor metastasis

目的探索恶性肿瘤由稳定期发展至转移期的血小板变化规律，筛选转移期的血小板截断值。方法同顺性分析30例经标准治疗后由稳定期发展至转移期的癌症患者转移前后的血小板计数，采用配对样本t检验分析血小板变化与发生转移的关系；通过绘制ROC曲线图，找出转移期血小板的临界值。结果患者转移期血小板计数增高，稳定期和转移期巾t小板差异有统计学意义（P〈0．05）；转移期血小板截断值为271×10^9／L，其灵敏度为64％，特异度为95％。结论恶性肿瘤由稳定期发展至转移期时血小板计数呈明显升高趋势。血小板计数〈271×10^9／L时，其发生转移的可能性较小；而血小板计数〉271×10^9／L时，应考虑病情恶化的可能性。

Objective To study the variation regularity of platelets in cancer patients from the stable stage to metastasis after standard treatment and to screen the cutoff value of platelets in tumor metastasis. Methods The platelets of thirty cancer patients from the stable stage to tumor metastasis after standard treatment were retrospectively analyzed. Platelet counts relative to metastasis were an- alyzed by paired - samples t - test. The cutoff value of platelets during tumor metastasis was identifyed by drawing the ROC curve. Result The platelet counts increased in patients with tumor metastasis. There was significant difference in platelet counts between the stable group and metastatic group （ P 〈 0.05 ）. Through the ROC curve, the cutoff value of platelets during tumor metastasis was 271 ×10^9/L, sensitivity 0.64, and specificity 0.95. Conclusions The platelet count tends to increase significantly in cancer patients from the stable stage to the metastasis stage. When the platelet count is 〈 271 ×10^9/L, tumor metastasis is less likely, but when it is 〉 271×10^9/L, deterioration is possible.