摘要
目的探讨转录因子Sp1在乳腺癌中的表达及意义。方法采用免疫组化方法检测转录因子Sp1在53例乳腺浸润性导管癌2、5例导管内癌组织和13例乳腺囊性增生病组织中的表达。结果 Sp1在乳腺浸润性导癌、导管内癌及乳腺囊性增生组织中表达逐渐降低,有统计学意义。在浸润性导管癌中其表达与病理分级、脉管浸润和腋窝淋巴结转移显著相关。结论 Sp1与乳腺浸润性导管癌的发生、发展及淋巴结转移关系密切。
Objective To evaluate the expression level and clinical significance of transcription factor Sp1 in breast carcinoma.Methods The expression level of Sp1 protein in 53 cases of invased breast ductal carcinoma,25 cases of breast intraductal carcinoma and 13 cases of cystic hyperplasia of breast were tested by the method of immunohistochemistry.Results The positive expression rate of Sp1 in invased ductal breast carcinoma was higher than that of intraductal carcinoma and cystic hyperplasia of breast.The positive expression level of Sp1 was rising with the upgrading of the breast invased ductal carcinoma pathological classification.Conclusion Sp1 is closely related with the carcinogenesis and development of breast ductal carcinoma.
出处
《临床医学》
CAS
2011年第11期5-6,F0003,共3页
Clinical Medicine
关键词
SP1
乳腺癌
免疫组织化学
Breast carcinoma
Sp1
Immunohistochemistry
