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糖基化终末产物、氧化应激和糖尿病肾脏病 被引量：3

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摘要 糖尿病。肾脏病（diabetickidneydisease，DKD）是糖尿病最常见的慢性并发症之一，也是引起慢性肾脏病最常见的原因。据世界卫生组织预测，2030年全世界的糖尿病人口数将达到3．7亿，但是，对于血糖或血压的强化治疗很难维持，而且可能增加低血糖和低血压的风险。糖尿病所致的慢性肾脏病人数仍在增加，所以，对于探索新的治疗方法十分必要。
作者 吴蓉（综述） 李建华（审校）
机构地区 兰州大学第一医院肾病科
出处 《临床肾脏病杂志》 2011年第11期525-527,共3页 Journal Of Clinical Nephrology
关键词 慢性肾脏病 糖基化终末产物 糖尿病 氧化应激 世界卫生组织 慢性并发症 强化治疗 治疗方法
分类号 R692 [医药卫生—泌尿科学]
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参考文献22

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同被引文献41

  • 1Gelasco AK, Raymond JR. Indoxyl sulfate induces compiex redox alterations in mesangial cells. Am J Physiol Renal Physi- ol,2006,290 : F1551-F1558.
  • 2Muteliefu G, Enomoto A, Niwa T. Indoxyl sulfate promotes proliferation of human aortic smooth muscle cells by inducingoxidative stress. J Ren Nutr, 2009,19 : 29-32.
  • 3Hsu CC, Lu YC, Chiu CA, et al. Levels of indoxyl sulfate are associated with severity of coronary atherosclerosis. Clin Invest Med, 2013,36 : E42-E49.
  • 4Yamamoto H, Tsuruoka S, Loka T, et al. Indoxy sulfate stimu- lates proliferation of rat vascular smooth muscle cells. Kidney In, 2006,69 : 1780-1785.
  • 5Shimizu H,Hirose Y, Nishijima F, et al. ROS and PDGF-beta Ecorreeted receptors are critically involved in indoxyl sulfate actions that promote vascular smooth muscle cell proliferation and migration. Am J Physiol Cell Physiol, 2009, 297: C389- C396.
  • 6Niwa T,Shimizu H. Indoxyl sulfate induces nephrovascular se nescence. J Ren Nutr,2012,22:102-106.
  • 7Wassmann S, Laufs U, Muller K, et al. Cellular antioxidant effects of atorvastatin in vitro and in vivo. Arterioscler Thromb Vasc Biol, 2002,22 : 300-305.
  • 8Balakamar P, Kathuria S, Taneja G, et al. Is targeting eNOS a key mechanistic insight of cardiovascular defensive potentials of stain?. J Mol Cellular Cardiol, 2012,52 : 82-93.
  • 9Niwa T. Indoxyl sulfate is a nephro-vascular toxin. J Ren Nu- tr,2010,20:S2-S6.
  • 10Muteliefu G, Shimizu H, Enomoto A, et al. Indoxyl sulfate prQ- motes vascular smooth muscle cell senescence with upregula- tion of p53, p21, and prelamin A through oxidative stress. Am J Physiol Cell Physiol,2012,303:C126-C134.

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二级引证文献8

临床肾脏病杂志
2011年 第11期

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