摘要
A series of 2,5-disubstituted pyrimido[5,4-c]quinoline derivatives were synthesized and their cytotoxic activity against H460, HT-29 and MDA-MB-231 cell lines was evaluated in vitro.It was found that most of the tested compounds especially compound 17, shown stronger activity to the selected three cell lines than ZM447439.
基金
supported by the Grant from National S & T Major Project of China(No2009ZX09301-012)
