头颈部肿瘤患者营养指标与放疗急性毒性反应相关分析

Relationship between acute radiotoxicity and nutritional status of patients with head and neck cancer

目的探讨头颈部肿瘤患者各营养指标与放疗急性毒性不同反应之间的关系。方法前瞻性调查130名头颈部肿瘤患者在放疗第4周时的营养状况和急性放射毒性反应。采用典型相关分析法分析各营养指标与急性放射毒性不同反应之间的关系。结果患者营养状况的各项指标(血清前白蛋白、转铁蛋白、淋巴细胞、淋巴细胞百分比)与放疗急性毒性反应的各项指标(口干、咽/咽喉炎、疲劳、放射性皮炎)之间存在负相关关系,第一典型相关系数为0.653,有统计学意义。结论当血清前白蛋白、转铁蛋白、淋巴细胞、淋巴细胞百分比的检测值偏低时,及时给予营养支持,提高机体免疫力可以减轻口干、咽/咽喉炎等放射毒性反应发生的程度和数量。

Objective To investigate the relationship between nutritional status and acute radiotoxicity of patients with head and neck cancer.Methods Nutritional status and acute radiotoxicities of 130 head and neck cancer patients were prospectively surveyed during the 4th week of radiotherapy.Relationships between nutritional status and acute radiotoxicities were analyzed by canonical correlation.Results The first canonical correlation coefficient was 0.653,statistically significant,which showed that some negative relationships were found between nutritional status（such as serum prealbumin,transferring,lymphocytes,lymphocyte percentage） and acute radiotoxicities（such as dry mouth,throat /sore throat,fatigue,radiation dermatitis）of head and neck cancer patients.Conclusion When the detection value of serum prealbumin,transferrin,lymphocytes,lymphocyte percentage was below the normal,the appropriate nutritional support would be given to improve immunity and to relieve the acute radiotoxicitoes.