栀子在治疗肝脏疾病中的研究进展

Advance About Application of Gardenia jasminoides Ellis in Treatment of Heptic Diseases

对中药栀子对肝脏的保护及治疗作用进行了文献整理和分析。以Pubmed和Medline search 2个数据库为检索平台,以栀子及肝脏为联合检索词,深入研究了近20年来,国内、外文献36篇,并对其进行分析归纳,集中介绍中药栀子的保肝及治肝的作用。分别对肝功能的生化指标、GSTs系统及肝细胞凋亡等进行了系统的归纳,阐述了栀子的保肝作用;另外,对栀子抗肝癌、抗肝硬化、抗肝炎以及抗脂肪肝等方面的治肝作用进行了系统的总结。现阶段关于栀子的药效学研究仅局限于其中单一成分对肝脏的作用,却未能使中药多成分、多靶点联合作用的用药优势得以发挥,为了进一步将栀子开发成为保肝、治疗肝脏疾病的良药,还需要进行大量关于栀子有效成分群对肝脏疾病作用的实验研究。

In this paper we analyzed and organized the literatures about the protection and treatment actions of heptic diseases by Gardenia jasminoides.Both pubmed and medline basedata were used,and G.jasminoides combined with liver was considered as the retrieval term.About 36 papers from home or abroad during the past 20 years were reviewed to demonstrate the protection and treatment effects of G.jasminoides on heptic diseases.In order to elucidate the protective effects of G.jasminoides biochemical indicators represented heptic functions,GSTs system and apoptosis of heptic cells were considered as the research objects;while the treatment effects of G.jasminoides on heptic diseases including the functions of anti-hepatoma,anti-hepatic cirrhosis,anti-hepatitis and anti-fatty liver,et al,were summerized.Currently pharmacodynamic studies always focus on the mono-component in G.jasminoides,and the characters of traditional Chinese medicine which are multicomponents,multitargets and combined application could not be manifested.For improving the protection and treatment actions of heptic diseases by G.jasminoides,further research work about the action of the active components in G.jasminoides should be performed.