间质性蕈样肉芽肿一例

Interstitial granuloma fungoides： a case report

患者女，36岁，因躯干、四肢红斑、鳞屑伴瘙痒3年就诊。皮肤科检查：患者胸腹部、臀部可见边界不清的淡红斑，其上覆层状白色鳞屑。皮损组织病理学检查：真皮浅层单一核细胞灶状浸润，部分细胞有亲表皮性，亲表皮细胞有轻度异形，真皮中层胶原纤维束间可见单一核细胞呈间质性浸润和少许黏蛋白沉积。真皮浅中层散在浸润的单一核细胞均阳性表达T辅助细胞免疫表型。诊断：间质性蕈样肉芽肿。

A 36-year-old woman presented with a 3-year history of pruritic erythema and scaling on the trunk and extremities. Dermatological examination revealed ill-defined light pink maeules with white lamellar scales on the chest, abdomen and buttocks. Histologically, there was a focal mononuclear cell infiltrate in the superficial dermis, with the epidermotropism of some cells and mild atypia of epidermotropic cells, as well as an interstitial mononuclear cell infiltrate and mild deposition of mucin between the collagen fibers in the middle dermis. CD3 and CD4 were expressed by scattered mononuclear cells infiltrating the upper and middle dermis. Based on these data, the patient was diagnosed with interstitial granuloma fungoides.