期刊文献+

阿托伐他汀治疗慢性心力衰竭疗效分析 被引量:1

下载PDF
导出
摘要 目的:探讨慢性心力衰竭的治疗方法。方法:将76例慢性心力衰竭患者随机分为对照组和观察组各38例,对照组采用强心、利尿、降血脂、抗凝药物常规治疗;治疗组在上述常规治疗的基础上,服用阿托伐他汀20 mg,1次/d治疗。疗程均为9个月,治疗前及治疗后6个月观察两组临床疗效,分别经多普勒超声测量左室射血分数(LVEF),左室收缩末容积指数(LVESVI)和左室舒张末容积指数(LVEDVI)。结果:治疗组治疗前后自身比较LVEF有显著改善(P<0.05),治疗后组间比较治疗组LVEF高于对照组,差异有统计学意义(P<0.05),无不良反应发生。结论:阿托伐他汀治疗慢性心力衰竭安全有效,能进一步改善慢性心力衰竭患者的心脏功能。
作者 赵鹏 李文跃
出处 《吉林医学》 CAS 2011年第33期7038-7039,共2页 Jilin Medical Journal
  • 相关文献

参考文献3

二级参考文献26

  • 1赵水平,胡大一.2007年ACC/AHA及ESC对NSTEACS诊疗指南,摘自《心血管病诊疗指南解读》(第三版),人民卫生出版社.
  • 2Holschermann H,Schuster D,Parviz B,et al.Statins prevent NF-kappa B transactivation independently of the IKK-pathway in human endothelial cells[J].Atherosclerosis,2006,185(2):240-245.
  • 3Kim YS,Ahn Y,Hong MH,et al.Rosuvastatin suppresses the inflammatory responses through inhibition ofc-JunN-terminalkinase and nuclear factor-kappaB in endothelial cells[J].J Cardiovasc Pharmacol,2007,49(6):376-383.
  • 4Ali F,Hamdulay SS,Kinderlerer AR,et al.Statin-mediated cytoprotection of human vascular endothelial cells:a role forKruppel-like factor2-dependent induction of heme oxygenase-1[J].J Thromb Haemost,2007,5(12):2537-2546.
  • 5Cirillo P,Pacileo M,de Rosa S,et al.HMG-CoA reductase inhibitors reduce nicotine-induced expression of cellular adhesion molecules in cultured human coronary endothelial cells[J].J Vasc Res,2007,44(6):460-470.
  • 6Deschaseaux F,Selmani Z,Falcoz PE,etal.Two types of circulating endothelial progenitor cells in patients receiving long term therapy by HMG-CoA reductase inhibitors[J].Eur J Pharmacol,2007,562(1-2):111-118.
  • 7Bauersachs J, Galuppo P, Fraccarollo D, et al. Improvement of left ventricular remodeling and function by hydroxymethylglutaryl coenzyme A reductase inhibition with cerivastatin in rats with heart failure after myocardial infarction [J]. Circulation, 2001
  • 8Hayashidani S, Tsutsui H, Shiomi T, et al. Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction [J]. Circulation, 2002, 105:868
  • 9Patel R, Nagueh SF, Tsybouleva N, et al. Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy [J]. Circulation, 2001,104:317
  • 10Laufs U, La Fata V, Plutzky J, et al. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors [J]. Circulation, 1998, 97:1129.

共引文献31

同被引文献5

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部