慢性阻塞性肺疾病治疗策略思考

Thinking about therapeutic strategy of chronic obstructive pulmonary disease

慢性阻塞性肺疾病(COPD)具有气流受限部分可逆特征,系因气道慢性炎症和重构所致,可伴有全身炎症表现和肺外并存疾病。慢性全身性炎症可能导致COPD和并存疾病的共同发病。抗炎治疗亦可作用于全身性炎症和肺外并存疾病,而治疗并存疾病亦有助于COPD的恢复。因此,治疗COPD应同时评估并存疾病,采用综合治疗措施。

Chronic obstructive pulmonary disease （COPD） is characterized by poorly reversible airflow limitation, resulting from chronic airway inflammation and remodeling. It may be associated with systemic inflammatory manifestation and extrapulmonary comorbidities. Chronic systemic inflammation may be the common pathway linking these combiordities. The treatment of COPD inflammation may affect the systemic inflammation and comorbidities simultaneously, and to treat the comorbidities may provide benefit for COPD. Treating patient with COPD should evaluate for associated diseases beyond the lungs, and treating patients with COPD must be a multidimensional approach.