摘要
对分化型甲状腺癌(DTC)预后相关因素进行分析并复习文献,为提高DTC诊断治疗水平及生存率提供依据。回顾性随访分析经术后组织病理学证实为DTC的150例(女性113例,男性37例)病例资料,乳头状癌131例(87.3%),滤泡癌19例(12.7%)。随访4.15~31年,存活140例(93.3%),复发30例(20.0%),死亡10例(6.7%)。手术方式中近全或次全切手术83例(55.3%),局部切除64例(42.7%),全切3例(2.0%)。63例行淋巴结切除者中45例(71.4%)检出淋巴结转移。发病年龄、就诊时肿瘤大小及早期转移率在死亡组与存活组、复发组与未复发组间有统计学差异(P〈0.05)。年龄、就诊时肿瘤大小及早期转移影响DTC预后。
Prognostic factors of differentiated thyroid carcinomas ( DTC ) were analyzed and the related literatures were systematically reviewed in order to justify the diagnostic and therapeutic modalities for improving the patient's survival. 150 patients ( female, n = 113 ; male, n = 37 ) with histopathologically diagnosed DTC, including papillary thyroid carcinoma ( n = 131, 87.3% ) and follicular thyroid carcinoma ( n = 19, 12. 7% ), were postoperatively followed up and their clinical data were retrospectively reviewed. Patients were followed up for 4. 15- 31 years wherein 140 patients(93.3% )survived but with relapse in 30 patients (20. 0% ), and 10 patients (6. 7% ) died. Surgical procedures consisted of near-total or subtotal thyroidectomy ( n = 83, 55.3% ), partial thyroidectomy ( n = 64, 42. 7 % ), and total thyroidectomy ( n = 3, 2. 0% ). Out of the patients receiving lymph node dissection ( n = 63), 45 patients(71.4% )had detectable lymph node metastasis. Age of onset, tumor size at initial visit, and early metastasis showed the statistically significant difference between mortality group and survival group (P 〈 0. 05 ), as well as between relapse group and relapse-free group ( P〈0. 05 ). Age of onset, tumor size at initial visit, and early metastasis are prognostic factors for DTC.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2011年第11期920-922,共3页
Chinese Journal of Endocrinology and Metabolism
基金
卫生部行业专项基金(201002002)
关键词
分化型甲状腺癌
预后
Differentiated thyroid carcinoma
Prognosis