期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

吡格列酮对肥胖小鼠原代棕色脂肪细胞分化和功能基因表达的影响 被引量：3

Effects of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells in mice with diet-induced obesity
原文传递
导出
摘要 观察吡格列酮对肥胖小鼠原代棕色脂肪（brown adipose tissue，BAT）细胞分化和功能基因表达的影响，并为治疗肥胖相关疾病寻找新思路。结果显示吡格列酮通过增强特异基因表达、促进分化成脂、提高线粒体功能等方面增强BAT细胞功能（P〈0．05）；这可能是吡格列酮改善机体代谢的重要原因。 The effect of pioglitazone on the expression of genes relative to differentiation and function of primary brown adipose tissue cells was detected for the new treatment of obesity and type 2 diabetes. The results showed that pioglitazone promoted the differentiation and function of brown adipocytes（ P〈0.05 ）.
作者 胡淼 刘娟 王龙 丁国宪
机构地区 南京医科大学第一附属医院老年内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2011年第11期947-949,共3页 Chinese Journal of Endocrinology and Metabolism
基金 国家自然科学基金资助项目（30900504）
关键词 吡格列酮 棕色脂肪 PPARΓ 解耦联蛋白1 Pioglitazone Brown adipose tissue PPARγ Uncoupling protein-1
分类号 R589.2 [医药卫生—内分泌]
  • 相关文献

参考文献14

  • 1Braissant O, Foufelle F, Scotto C, et al. Differential expression of peroxisome proliferator-activated receptors (PPARs) : tissue distribution of PPARca, β and β in the adult rat. Endocrinology, 1996, 137:354-366.
  • 2Farmer SR. Molecular determinants of brown adipocyte formation and function. Genes Dev, 2008,22 : 1269-1275.
  • 3Collins SKW, Daniel E, Petro AE, et al. Strain-specific response to beta 3-adrenergic receptor agonist treatment on diet-induced obesity in mice. Endocrinology, 1997,138:405-413.
  • 4Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab, 2007,293 : FA44-EA52.
  • 5Ravussin E, Kozak LP. Have we entered the brown adipose tissue renaissance? Obesity, 2009,10:265-268.
  • 6Cannon B, Nedergaard J. Neither fat nor flesh. Nature, 2008,454:947- 948.
  • 7Issemann I, Green S. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature, 1990,347: 645 -650.
  • 8Okuno A, Tamemoto H, Tobe K, et al. Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest, 1998,101 : 1354-1361.
  • 9Miles PD, Romeo OM, Higo K, et al. TNF-a induced insulin resistance in vivo and its prevention by troglitazone. Diabetes, 1997,46:1678- 1683.
  • 10World Health Organization 2008 Global strategy on diet, physical activity and health. Accessed on May 15,2008. ADP.

同被引文献46

引证文献3

二级引证文献7

中华内分泌代谢杂志
2011年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部