摘要
目的:使用IBM SPSS Statistics软件设计合成3,5-二氯对氨基苯磺酰胺,优化实验条件。方法:选择原料配比、H_2O_2用量、H_2O_2滴加时间三因素设计正交实验,将实验结果输入IBM SPSS Statistics软件,分析得到正交实验方差表和单因素统计表,并对实验数据进行统计分析,得到实验的优化条件。结果:3,5-二氯对氨基苯磺酰胺制备的最佳条件是:原料配比n(C_6H_6N_2O_2S):n(30%HCI质量分数)=1:17,H_2O_2用量1mol,H_2O_2滴加时间60min。收率达80.8%,熔点为204℃～205.5℃。结论:IBM SPSS Statistics软件具有强大的试验设计和数据统计分析功能,而且使用方便、计算精确、结论可靠,避免了大量人工计算,可以迅速分析出3,5-二氯对氨基苯磺酰胺有机合成工艺中的优化条件,值得在有机合成工艺优化中推广。
3,S-dichlorosulfanilamide was designed and synthesized,experimental data was analyzed by IBM SPSS Statistics software.The orthogonal was designed by the effect of molar ratio,the amount of H_2O_2 and the addition time of H_2O_2,test results were inputted to the IBM SPSS Statistics software and analyzed,analysis of variance and statistics of single factor were got,and optimization conditions were determined as follows： n（C_6H_6N_2O_2S）：（30%HCl）=1：17,the amount of H_2O_2 was 1.0 mol,the time needed for the addition of H_2O_2 was 60 minutes.The yield of product is 80.8%,melting point is 204℃～205.5℃.IBM SPSS Statistics software has a strong experimental design and data statistical analysis,the conclusion was reliable and at the same time,a great deal of manual calculation was avoided.The optimal conditions of the organic synthesis process
出处
《计算机与应用化学》
CAS
CSCD
北大核心
2011年第11期1425-1427,共3页
Computers and Applied Chemistry
基金
江苏大学高级人才基金(No.11JDG056)
江苏省高校自然科学基金(09KJB530001)
关键词
IBM
SPSS
STATISTICS
优化
3
5-二氯对氨基苯磺酰胺
合成
IBM SPSS were analyzed quickly
so it is worth to popularize IBM SPSS Statistics in the technical optimization of organic synthesis
statistics
optimization
3
5-dichlorosulfanilamide
preparation
