抗原口服耐受性影响因素的研究进展

Progress on the influencing factors of oral tolerance to antigens

抗原口服耐受性是经口接触某种抗原物质后机体再次接触这种抗原时对其免疫应答的主动抑制。机体每天都要接触大量的食物抗原,而抗原口服耐受性的存在使绝大部分人不会对这些抗原产生过敏反应。食物致敏性是人们关注的热点之一,通过建立动物模型来研究食物致敏性是一条比较直接的途径,而降低实验动物的口服耐受性可有效提高该模型的检出效力。本文就近年来口服耐受性影响因素及消除口服耐受性的措施或方法方面的研究进展进行综述。

Oral tolerance refers to a state of active inhibition of immune response to a food antigen which has been exposed previously via oral route.With exposure to a large extent of food antigens every day,adverse immunologic reactions to an antigen only take place in a small proportion of individuals because of the existence of oral tolerance.Food allergy is one of hot topics in related fields.Establishing an animal model is a direct way to explore food allergy.Avoiding oral tolerance of an animal to antigens could improve the detection efficiency of the model.The progress on the research of factors influencing oral tolerance to food antigens is reviewed.