miRNA与乳腺癌发生发展和多药耐药的研究现状

Effect of microRNA in progressing of breast cancer and drug resistance

目的:总结近期国内外有关微小RNA(miRNA)在乳腺癌发生发展和多药耐药中作用的研究进展。方法:应用Pubmed和CNKI期刊全文数据库检索系统,以"miRNA、乳腺癌耐药和耐药相关蛋白"为关键词,检索2008-01-2011-03有关miRNA在乳腺癌发生发展和多药耐药中作用的文献。纳入标准:1)miR-NA在乳腺癌发生发展中的作用。2)miRNA通过调控耐药蛋白表达参与乳腺癌多药耐药。根据纳入标准分析33篇文献。结果:多种miRNA与乳腺癌的发生发展及侵袭转移和复发密切相关。其中,能够促进乳腺癌侵袭转移的miRNA少有报道,目前仅有miR-373和miR-21。多种miRNA能够抑制乳腺癌侵袭转移,如:miR-340、miR-1258、miR-520b、miR-206、miR-19、miR-34和miR-199a/b。此外,多种miRNA参与乳腺癌多药耐药的形成过程。其中,miR-519c、miR-328和miR-520h3种miRNA可调控乳腺癌耐药蛋白(BCRP)表达,miRNA-451可调控P糖蛋白(P-gp)表达,miR-326可调控多药耐药相关蛋白(MRP)表达从而参与乳腺癌多药耐药。结论:深入研究miRNA在乳腺癌发生及多药耐药中的作用将为乳腺癌的治疗提供新的有效靶点。

OBJECTIVE： To review the progress of research on the effect of microRNA in progressing of breast cancer and drug resistance. METHODS： WithmiRNA;breast cancer drug resistance; drug resistance related protein as key words,the literature was searched in Pubmed and CNKI databases between 01-2008 and 03-2011. Choice criteria： 1） The effect of microRNA in progressing of breast cancer; 2） The effect of microRNA in multidrug resistance. A total of 33 litera- tures were selected. RESULTS= Recent studies demonstrated that the disorder expression of some microRNAs is associated with breast cancer. The microRNAs play important roles in proliferation,metastasis of breast cancer. There are just miR- 373 and miR-21 are reported to promote metastasis of breast cancer at present. By contrast, miR-340, miR-1258, miR-520b, miR 206 ,miR-19 ,miR 34 and miR-199a/b have been reported to prevent breast cancer metastasizing. Moreover,the microRNAs play important roles in multidrug resistance of breast cancers. MiR 519c,miR-328 and miR-520h can regulate the expression of breast cancer resistance protein（BCRP）, miRNA-451 can regu- late the expression of P-glycoprotein （P-gp）, and miR 326 can regulate the expression of multidrug resistance-associated protein（MRP）. CONCLUSION Further research on the effect of microRNA in progressing of breast cancer and drug resistance will bring new effective targe for breast cancer therapy.