右美沙芬降低组胺肺功能激发试验假阳性率

Dextromethorphan reduces false-positive rate in bronchial provocation test with histamine

目的:探讨组胺激发试验过程中咳嗽不良反应与阳性率的关系。方法:选取我院呼吸内科行组胺支气管激发试验患者120例,随机分为两组,试验前10 min分别予氢溴酸右美沙芬口服溶液30 mg与安慰剂口服,以咳嗽量表评价激发试验过程中咳嗽剧烈程度,并记录激发试验测试结果。3 d后试验组激发试验阴性患者于试验前10 min口服安慰剂重新行激发试验。结果:试验组重度咳嗽发生率较对照组低;试验组重度咳嗽患者支气管激发试验阳性率亦较对照组下降;试验组激发试验阴性患者予安慰剂重复激发试验,结果仍全部为阴性。结论:氢溴酸右美沙芬可通过减轻咳嗽不良反应减少重度咳嗽的发生率,从而降低组胺肺功能试验假阳性率,且未出现明显假阴性。

Objective： To investigate the relationship between cough side-effect and false-positive rate in bronchial provocation test with histamine.Methods： A total of 120 patients were enrolled and randomly divided into 2 groups.Patients were treated with either oral solution of dextromethorphan hydrobromide or placebo 10 min before bronchial provocation test.The severity of cough was evaluated by cough scales.Results： The incidence rate of grade 3 cough side-effect and the positive rate of patients with grade 3 cough-side effect were lower in dextromethorphan group than in control group.No positive result was found in repeated tests of bronchial provocation 3 days after the first test in patients with negative result of dextromethorphan group.Conclusion： Dextromethorphan hydrobromide can relieve cough side-effect and thereby reduce false-positive rate in bronchial provocation test with histamine.