1,3-二取代-2-硫代咪唑啉-4-酮的合成

Synthesis of 1,3-Disubstituted-2-thioxo-4-imidazolidinones

1-苯甲酰基-3-芳基硫脲与氯乙酰氯反应合成了1-芳基-3-苯甲酰基-2-硫代咪唑啉-4-酮,与二氯乙酰氯反应合成了1-芳基-3-苯甲酰基-5-氯-2-硫代咪唑啉-4-酮,与三氯乙酰氯反应时仅得到了硫脲的分解重组产物苯甲酰基芳胺.产物结构经红外光谱、核磁共振谱和高分辨质谱表征.

3-Aryl-1-benzoylthiourea reacted with chloroacetye chloride to afford 1-aryl-3-benzoyl-2-thi-oxo-4-imidazolidinones in 70%～84% yields in the presence of alkaline.However,using dichloroacetye chloride instead of chloroacetye chloride,1-aryl-3-benzoyl-5-chloro-4-imidazolidinones were obtained in 36%～53% yields.The structures of the products were confirmed by IR,1H NMR and HRMS techniques.