33例胃印戒细胞癌的临床分析

Clinical analysis of 33 cases of gastric signet ring cell carcinoma

目的探讨胃印戒细胞癌的临床病理特征及预后。方法回顾性分析166例胃癌患者中印戒细胞癌与非印戒细胞癌的临床病理特征及术后生存情况的差异。结果 166例胃癌中印戒细胞癌为33例(19.9%),非印戒细胞癌133例(80.1%),两者性别、病变部位、分化程度、肿瘤浸润深度、淋巴结转移、有无远处转移及临床分期等差异均无统计学意义(P>0.05);而两者年龄分布差异显著(P=0.032),印戒细胞癌中60岁以下患者更多见;印戒细胞癌中侵犯神经的比例也明显高于非印戒细胞癌(P=0.021)。印戒细胞癌患者的4年生存率为42.4%,明显低于非印戒细胞癌患者的66.2%(P<0.05)。结论相对于非印戒细胞癌,胃印戒细胞癌的发病年龄轻,神经侵犯比例高,预后差。

Objective To study the pathological characters and prognosis of 33 cases of gastric signet ring cell carcinoma.Methods The difference of clinicopathology and survival between signet ring cell carcinoma and non-signet ring cell carcinoma in 166 gastric cancer patients were analyzed restropectively.Results Thirty-three gastric signet ring cell carcinoma was observed in 166 gastric cancer samples（19.88%） and had no relationship with general pathological characters such as sex,lesion location,differentiation,depth of infiltration,lymph node metastasis,distant metastasis and clinical stage（P〉0.05）.Gastric signet ring cell carcinoma patients were younger（age〈60,P=0.032） and had higher ratio of neural invasion（P=0.021） than those of non-signet ring cell carcinoma patients.The gastric signet ring cell carcinoma patients had poorer 4 years survival rate（42.4%） than that of non-signet ring cell carcinoma patients（66.2%）,showing significant differences（P〈0.05）.Conclusion The gastric signet ring cell carcinoma has a worse prognosis compared to non-signet ring cell carcinoma.