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FOXP1在肿瘤发生和发展中的作用 被引量：6

Effect of FOXP1 on the occurrence and development of tumors
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摘要 FOXP1是FOXP亚家族(FOXP1-4)转录因子的成员,广泛表达于人心肌、肺、小肠、淋巴等组织细胞,具有多种生物学功能。FOXP1也表达于多种肿瘤细胞,在不同的肿瘤组织中FOXP1可能有不同的生物学作用。 Forkhead box p1（FOXP1） is a member of the FOXP family（FOXP1-4） of transcription factors which widely expresses in heart,lung,foregut,brain and lymph,and has a broad range of functions.FOXP1 also expresses in a variety of tumor cells which may have different biological actions.
作者 胡成如 王靖华
机构地区 南京大学医学院临床学院南京军区南京总医院肿瘤内科
出处 《临床肿瘤学杂志》 CAS 2011年第11期1052-1055,共4页 Chinese Clinical Oncology
关键词 FOXP1 肿瘤 FOXP1 Tumor
分类号 R730 [医药卫生—肿瘤]
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参考文献22

  • 1Gaynor J. Bates,Stephen B. Fox,Cheng Han,Rosalind Launchbury,Russell D. Leek,Adrian L. Harris,Alison H. Banham.Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptorβ in primary invasive breast carcinomas[J]. Breast Cancer Research and Treatment . 2008 (3)
  • 2Philip Brown,Teresa Marafioti,Rajko Kusec,Alison H. Banham.The FOXP1 Transcription Factor is Expressed in the Majority of Follicular Lymphomas but is Rarely Expressed in Classical and Lymphocyte Predominant Hodgkin’s Lymphoma[J]. Journal of Molecular Histology . 2005 (4)
  • 3Horn D,Kapeller J,Rivera-Brugues N,et al.Identification ofFOXP1 deletions in three unrelated patients with mental retarda-tion and significant speech and language deficits. Human Mutation . 2010
  • 4Pariani MJ,Spencer A,Graham JM,et al.A 785 kb deletion of3p14.1p13,including the FOXP1 gene,associated with speechdelay,contractures,hypertonia and blepharophimosis. Eur JMed Genet . 2009
  • 5Nyman H,Jerkeman M,Leppa S.Bcl-2 but not FOXP1,is anadverse risk factor in immunochemotherapy-treated non-germinalcenter diffuse large B-cell lymphomas. European Journal of Haematology . 2009
  • 6Alison H,Banham AH,Philip J,et al.Expression of the FOXP1transcription factor is strongly associated with inferior survival inpatients with diffuse large B-cell lymphoma. Clinical Cancer Research . 2005
  • 7Hoeller S,Schneider A,Haralambieva E,et al.FOXP1 proteinoverexpression is associated with inferior outcome in nodal diffuselarge B-cell lymphomas with non-germinal centre phenotype,in-dependent of gains and structural aberrations at 3p14.1. Histopathology . 2010
  • 8Preusser M,Woehrer A,Koperek O,et al.Primary central nerv-ous system lymphoma:a clinicopathological study of 75 cases. The Journal of Pathology . 2010
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同被引文献34

  • 1秦婧,王桂兰,徐玉音,陈莉.慢病毒介导的siRNA沉默Foxp1对肝癌细胞增殖、凋亡和迁移的影响[J].肿瘤防治研究,2014,41(4):309-315. 被引量：2
  • 2张莹,张勇,蔡本志,冯铁明,李宝馨,乔国芬,王玲,吕延杰,杨宝峰.microRNA在犬心房纤颤模型中的变化[J].哈尔滨医科大学学报,2007,41(2):92-94. 被引量：16
  • 3Banham AH, Beasley N, Campo E, et al. The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p [J]. Cancer Res, 2001,61 (88) :8220-8229.
  • 4Koon HB, Ippolito GC, Banham AH, et al. FOXP1 : a potential therapeutic target in cancer [ J ]. Expert Opin Ther Targets, 2007, 11 (7) :955-965.
  • 5Bari A, Marcheselli L, Sacchi S, et al. Prognostic models for diffuse large B-cell lymphoma in the rituximab era: a never-ending story [J]. Ann Oncol, 2010, 21 (7) : 1486-1491.
  • 6Brown PJ, Ashe SL, Leich E, et al. Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL [J]. Blood, 2008,111 (5) : 2816-2824.
  • 7Streubel B, Vinatzer U, Lamprecht A, et al. T ( 3 ; 14 ) ( p14 ; q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma[J]. Leukemia, 2005,19 (4) : 652-658.
  • 8Barrans SL, Fenton JAL, Banham A, et al. Strong expression of FOXP1 identifies a distinct subset of diffuse large B-cell lymphoma(DLBCL) patients with poor outcome[J]. Blood, 2004, 104 (9) :1933-1935.
  • 9Banham AH, Connors JM, Brown PJ, et al. Expression of the FOXP1 transcription factor is strongly associated with inferior survival in patients with diffuse large B-cell lymphoma [J]. Clin Cancer Res, 2005, 11 (3) : 1065-1072.
  • 10Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray [J]. Blood, 2004, 103( 1 ) :275-282.

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临床肿瘤学杂志
2011年 第11期

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