氮杂环卡宾催化苯偶酰的高效合成

Efficient synthesis of benzil catalyzed by N-heterocyclic carbenes

以苯甲醛为起始原料,利用氮杂环卡宾作为有机催化剂,氧气为氧化剂,在乙醇的碱性溶液中,通过一锅内的苯甲醛安息香缩合反应和苯偶姻的氧化反应,提供了一种制备苯偶酰的高效简捷方法。无需分离中间产物便可一步获得目标产物苯偶酰。

Benzaldehyde was chosen as starting material,N-heterocyclic carbene was utilized as organic catalyst,and oxygen as the oxidant.Under the base conditions,benzil was efficiently prepared by the way of benzion condensation followed oxidation in one pot.Benzil can be easily obtained without separation of intermediate compound.