聚乳酸微球的制备

Preparation of polylactic acid microspheres

以L-乳酸为原料,锡粒为催化剂,实现了丙交酯的开环聚合反应,红外光谱结果表明,合成了分子量可控的聚乳酸。以二氯甲烷为溶剂,聚乙烯醇为表面活性剂,制备了聚乳酸微球,研究了聚乙烯醇浓度对聚乳酸微球的影响。结果表明,当聚乙烯醇浓度增加时,微球半径变小,但粒径分布均匀度下降,聚乙烯醇浓度为1%时,聚乳酸成球效果较好。

Using L-lactic acid as raw materials and tin as a catalyst,and through the activity of lactide ring-opening polymerization,the controlled molecular weight polylactic acid was synthesized.FTIR results showed that controlled molecular weight polylactic acid was synthesized.Using dichloromethane as solvent,polyvinyl alcohol as surfactant,polylactic acid microspheres were prepared.Effect of PVA concentration on the polylactic acid microspheres was researched.Results showed that when the PVA concentration increased,the microspheres became smaller,but the particle size distribution decreased.Concentration of PVA was 1%,polylactic acid into the ball was better.