摘要
心力衰竭(心衰)是由多种心血管疾病引起的心功能不全,最终出现心肌局部坏死和不可逆转的纤维化。传统的药物治疗、介入和外科治疗方案都存在着一定的局限性。随着转化医学的发展,心脏再生和修复无疑是解决以上临床问题的最佳方案,基础研究的成果正在为临床实践提供理论基础。文章从心脏再生性修复策略、心肌细胞来源、重编程和模式动物等几个方面的进展概括了整个心脏再生领域的发展。
Heart failure（CHF） is the direct cause of death of a variety of cardiovascular diseases,culminating in irreversible myocardial necrosis and fibrosis.Traditional drug treatment,intervention,and surgical treatment have their own limitations.Increasing cardiac regeneration and repair of the injured heart is undoubtedly a promising approach to solve these clinical problems.In this paper,we summarized recent progress of heart development and regeneration,highlighting potential involvement of cell proliferation,dedifferentiation and cell reprogramming.We also proposed several fundamental and important research directions in this exciting area.
出处
《遗传》
CAS
CSCD
北大核心
2011年第11期1159-1163,共5页
Hereditas（Beijing)
基金
国家自然科学基金项目(编号:31000644)资助
关键词
心脏发育
心脏再生
模式动物
心肌梗塞
heart development
cardiac regeneration
model animal
myocardial infarction
