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MicroRNAs对斑马鱼发育的调控 被引量：5

Regulation of zebrafish development by microRNAs
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摘要 microRNAs(miRNAs)是一类长度约为22nt的非编码小RNA,从单细胞到多细胞真核生物中都广泛存在,在进化过程中高度保守,对动物发育、生理功能及病理过程都具有重要调控作用。斑马鱼(Danio rerio)是现代生物学研究中广泛使用的模式动物,以斑马鱼为模型研究miRNAs可以揭示miRNAs在脊椎动物中的功能。文章就miRNAs整体缺失对斑马鱼胚胎发育的影响及一些miRNAs在斑马鱼早期发育过程中的调控机制进行了综述,从而为探索miRNAs在脊椎动物中的功能及鱼类的生产育种提供理论基础。 MicroRNAs（miRNAs） are a class of non-coding small RNAs at the length about 22nt,which are found in the cells of both unicellular and multicellular eukaryotes,and highly conserved in many processes of biological evolution.miRNAs play important roles in the regulation of animal development,physiological functions,and pathological processes.As a model organism,zebrafish has been widely used in the modern biological researches.The studies on miRNAs in zebrafish are capable of revealing the function of miRNAs in vertebrate.This paper reviews the effects of total miRNA deletion and the individual miRNAs on the embryonic development of zebrafish in order to provide the clues for the functional researches of miRNAs on vertebrate and breeding in fish.
作者 丁雷 闫学春 孙效文 滕春波
机构地区 东北林业大学生命科学学院 中国水产科学研究院黑龙江水产研究所
出处 《遗传》 CAS CSCD 北大核心 2011年第11期1179-1184,共6页 Hereditas（Beijing)
基金 国家高技术研究发展计划(863计划)项目(编号:2009AA10Z105)资助
关键词 MICRORNAS 斑马鱼 发育 microRNAs zebrafish development
分类号 Q522 [生物学—生物化学]
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参考文献49

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