瑞舒伐他汀钙合用左旋氨氯地平对颈动脉粥样硬化及血管内皮功能的影响

Effects of combined use of rosuvastain and levamlodipine on carotid artherosclerosis and the function of vascular endothelium in essential hypertension patients

目的:观察左旋氨氯地平和瑞舒伐他汀钙的降压作用及对高血压患者颈动脉内膜-中膜厚度(IMT)及血管内皮功能的影响。方法:选择160例高血压伴动脉粥样硬化的患者,随机分为2组,实验组80例,服用苯磺酸左旋氨氯地平片2.5～5mg.d-1,瑞舒伐他汀钙10 mg,1次/晚。对照组80例,服用苯磺酸左旋氨氯地平片2.5～5 mg.d-1,疗程12个月,于治疗前后用彩色多普勒超声检测颈动脉内膜-中膜厚度,肱动脉内皮依赖性舒张功能,监测血压、血脂变化。结果:实验组治疗后血压下降较对照组显著,实验组治疗后颈动脉IMT较对照组显著减小(P<0.05),肱动脉内皮依赖性舒张功能显著改善(P<0.05)。结论:瑞舒伐他汀钙联合左旋氨氯地平能明显减轻颈动脉粥样硬化病变,可作为高血压并颈动脉粥样硬化的常规用药。

OBJECTIVE To study the effect of combined use of rosuvastain and levamlodipine on blood pressure, intimamedia thickness（IMT） and the function of vascular endothelium. METHODS 160 patients,with essential hypertension and carotid atherosclerosis,were divided randomly into 2 groups. 80 patients of test group were treated with levamlodipine 2. 5-5 mg·d-1 and rosuvastain 10 mg every night while levamlodipine 2. 5-5 mg·d-1 for 80 patients of control group for 12 months. Intimamedia thickness of carotid and brachial artery endothelium-dependent diastolic function were tested by color Doppler ultrasound before and after the therapy, the blood pressure and blood lipid were also monitored. RESULIS After the therapy,there were significant differences in blood pressure,IMT and brachial artery endothelium-dependent diastolic function between test group and control group. CONCLUSION levamlodipine could be the normal medication of carotid atherosclerosis for it can lower blood pressure greatly and improve atherosclerosis while combination with rosuvastain.