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CXCR1、CXCR2在口腔鳞癌中的表达及意义 被引量：3

Expression of CXCR1 and CXCR2 in human oral squamous cell carcinoma
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摘要 目的探讨CXCR1、CXCR2的表达与口腔鳞癌生物学行为的关系及意义。方法应用免疫组织化学技术检测57例口腔鳞癌手术切除标本和10例正常口腔黏膜标本中CXCR1、CXCR2的表达情况,分析其与病变类型及临床病理特征的关系。结果口腔鳞癌标本中41例(71.9%)CXCR1呈阳性表达,35例(61.4%)CXCR2呈阳性表达。CXCR1与口腔鳞癌的病理分级、临床分期及淋巴结转移关系密切,CXCR2与口腔鳞癌的临床分期及淋巴结转移关系密切。结论 CXCR1、CXCR2在口腔鳞癌的发生、发展中起重要作用,是口腔鳞癌早期诊断和预后的潜在生物学参考指标。 Objective To investigate the expression of chemokine receptors CXCR1 and CXCR2 in human oral squamous cell carcinoma.Methods The expression of CXCR1and CXCR2 was examined by immunohistochemical method in 57 cases of human oral squamous cell carcinoma and 10 cases of normal lingual mucosa.Its relationship with clinicopathological features and prognosis was analyzed.Results The expression of CXCR1 and CXCR2 was detected in 41 cases（71.9%） and 35 cases（61.4%） of oral squamous cell carcinoma respectively.The expression of CXCR1was significantly associated with tumor grade,clinical staging and lymph node metastasis;the expression of CXCR2 was significantly associated with clinical staging and lymph node metastasis of oral squamous cell carcinoma.Conclusion CXCR1 and CXCR2 might be associated with the development of oral squamous cell carcinoma.These two receptors are potential biomarkers for diagnosis and prognosis of oral squamous cell carcinoma.
作者 徐文华 程继光 王元银
机构地区 安徽医科大学附属口腔医院颌面外科
出处 《实用肿瘤杂志》 CAS 北大核心 2011年第6期618-621,共4页 Journal of Practical Oncology
关键词 癌 鳞状细胞/病理学 口腔肿瘤/病理学 受体 白细胞介素8A/生物合成 受体 白细胞介素8B/生物合成 淋巴结 基因表达 肿瘤转移 免疫组织化学 carcinoma squamous cell/pathology mouth neoplasms/pathology receptors interleukin-8A/biosynthesis receptors interleukin-8B/biosynthesis lymph nodes gene expression neoplasm metastasis immunohistochemistry
分类号 R739.8 [医药卫生—肿瘤]
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参考文献14

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共引文献5

同被引文献99

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实用肿瘤杂志
2011年 第6期

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