氯诺昔康预防气管拔管不良反应的临床观察

Observation on Lornoxicam Preventing the Adverse Reactions of Trachea Extubation

目的观察氯诺昔康预防气管拔管不良反应。方法 60例静吸复合麻醉下的手术患者,关腹膜后停用麻醉维持药,A组静脉给予氯诺昔康16mg,B组静脉注入曲马多100mg,C组静注生理盐水2mL。监测不同时点的平均动脉压(MAP)、HR和SpO2,并记录停止全麻维持药至拔除气管导管时间、清醒时间、出手术室时间及拔管时是否躁动和恶心、呕吐等。结果 16mg氯诺昔康和100mg曲马多均能有效预防气管拔管期的不良反应,组间差异无统计学意义(P>0.05)。结论氯诺昔康能有效预防气管拔管的不良反应,减少苏醒期躁动,不影响苏醒时间,值得临床推广。

Objective To observe on Lornoxicam preventing the adverse reactions of trachea extubation. Methods Sixty patients undertaken surgery combined anesthesia were divided into groups A,B and C. The patients were intravenously injected Lornoxicam 16mg, Tramadol 100mg and Sodium Chloride 2mL in groups A,B and C,respectively. MAP,HR and SpO2 were monitored at different time points. The duration from when the maintenance of anesthesia were stopped to extubation,awaking and going out of operating room and the side effects such as restlessness,nausea,vomitus were recorded. Results 16mg Lornoxieam and 100mg Tramadol could prevent the adverse reactions of extubation with no statistical differences（P〉0.05）. Conclusion Lornoxieam can effectively prevent the adverse effects of tracheal extubation and reduce restlessness during awaking.