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外科脓毒性脑病的发病机制和诊治对策 被引量：1

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摘要 外科感染后全身性炎性介质反应所致的弥漫性大脑功能障碍和意识改变，称为脓毒性脑病（Septic encephalopathy，SE）。大脑通常是脓毒症最早受累的器官，在其他器官出现症状之前，严重脓毒症即能引起大脑短暂的可逆或不可逆性脑损伤。然而，
作者 张庆红 姚咏明
机构地区 解放军总医院第一附属医院全军烧伤研究所
出处 《国际外科学杂志》 2011年第11期725-728,共4页 International Journal of Surgery
基金 国家自然科学基金资助项目（N030973120,No.30872683） 国家重点基础研究发展计划项目（No.2005CB522602）
关键词 外科脓毒性 发病机制 脑病 大脑功能障碍 严重脓毒症 诊治 意识改变 介质反应
分类号 R459.7 [医药卫生—急诊医学]
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参考文献16

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同被引文献25

  • 1王艳红,冯志杰,郝晓.急性胰腺炎与氧化应激[J].世界华人消化杂志,2007,15(11):1266-1272. 被引量：24
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  • 4Shiramizo SC, Marra AR, Durao MS, et al. Decreasing mortality in severe sepsis and septic shock patients by implementing a sepsis bundle in a hospital setting [ J]. PLoS One, 2011, 6 ( 11 ) : e26790.
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  • 7Galley HF, Davies M J, Webster NR. Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading[J]. Free Radic Bi- ol Med, 1996, 20(1) : 139-143.
  • 8Tyml K. Critical role for oxidative stress, platelets, and coagulation in capillary blood flow impairment in sepsis [ J ]. Microcirculation, 2011, 18(2): 152-162.
  • 9Secor D, Li F, Ellis CG, et al. Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries[ J]. Intensive Care Med, 2010, 36 (11) : 1928-1934.
  • 10Herkert O, Djordjevic T, BelAiba RS, et al. Insights into the red- ox control of blood coagulation: role of vascular NADPH oxidase- derived reactive oxygen species in the thrombogenic cycle [ J ]. An- tioxid Redox Signal, 2004, 6(4) : 765-776.

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国际外科学杂志
2011年 第11期

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