亚低温对创伤性脑损伤患者脑脊液β2-微球蛋白的影响

Effect of mild hypothermia on β2-microglobulin level in cerebro-spinal fluid of traumatic brain injury patients

目的通过随机分组研究亚低温对创伤性脑损伤患者脑脊液β2-微球蛋白水平的影响。方法将36例重型颅脑损伤患者随机分为亚低温治疗组及常温治疗组，研究在不同时间点脑脊液β2-微球蛋白的变化，并结合预后判断分析亚低温对重型颅脑损伤患者的影响。结果在治疗各时间点上脑脊液β2-微球蛋白含量为先增高后降低，两组比较发现，亚低温组β2-微球蛋白含量较常规治疗组在治疗后7天及14天明显降低（4．29±0．31，3．37±0．42，P〈0．05；3．04±0．29，2．26±0．31，P〈0．05），结合预后GOS评分，两组预后比较差异有统计学意义（亚低温组GOS4—5分50％，常规治疗组GOS4—5分31．25％，P〈0．05）。结论亚低温治疗可以通过抑制炎性介质反应及增强免疫调节等作用达到脑保护作用。

Objective To study the effect of mild hypothermia on β2-microglobufin（MG） level in cerebrospinam（CSF） of traumatic brain injury（TBI） patients. Methods Thirty-six severe TBI patients were divided into two groups randomly, mild hypothermia treatment group and normathermia treatment group, and the β2-MG level and GOS score in CSF of these patients in different time-point were evaluated. Results β2-MG level increased at first, then decreased gradually, and MBP level in mild hypothermia group decreased greater than the control group（ P 〈 0.05 ） , moreover, patients in mild hypothermia treatment group had better outcome than the control group （P 〈 0.05 ）. Conclusion Mild hypothermia may act as neuropro- tection by inhibiting inflammatory response or improving immune regulation.