[BPy][HSO_4]离子液体催化合成3,4-二氢嘧啶-2-酮

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Ionic Liquid[BPy][HSO_4]

经典的Biginelli反应用HCl作催化剂,通常产率较低(20%～50%).以[BPy][HSO4]离子液体为催化剂考察了Biginelli反应在不同温度和溶剂下的反应特点,合成了一系列3,4-二氢嘧啶-2-酮,产率70.7%～92.1%.该方法操作简单方便,产率、纯度较经典的Biginelli反应有较大的提高和改善,具有一定实用价值.

The classical Biginelli reaction,which uses hydrochloric acid as a catalyst,often has a low yield（20%-50%）.Ionic liquid was choosed as a catalyst to research the characteristic of Biginelli in different temperatures and solvents and a series of 3,4-dihydropyrimid in-2（1H）-ones were synthesized.The reactions were completed with 70.7%-92.1% yields.The new method not only preserves the simplicity of Biginelli＇s one-pot reaction,but also has a high yield.This is a worthiness way for the synthesis of dihydropyrimidinones.