N-1,3,5-二氢二噻嗪基乙酸、2-(N-1,3,5-二氢二噻嗪基)丙酸和3-苯基-2-(N-1,3,5-二氢二噻嗪基)丙酸的合成及其香气特征

Synthesis and aroma characteristic of N-1,3,5-dihydrodithiazinyl acetic acid,2-(N-1,3,5-dihydrodithiazinyl)propanoic acid and 3-phenyl-2-(N-1,3,5-dihydrodithiazinyl)propanoic acid

0℃下,在氨基酸的氢氧化钾溶液中,依次加入38%的甲醛、2mol/L的硫氢化钠溶液,充分搅拌反应,然后让其自然升至室温过夜,分别合成N-1,3,5-二氢二噻嗪基乙酸、2-(N-1,3,5-二氢二噻嗪基)丙酸和3-苯基-2-(N-1,3,5-二氢二噻嗪基)丙酸,收率分别为77.2%、73.7%和67.1%。这些化合物结构都通过IR、MS和1HNMR测试技术进行了表征,并对其进行了初步香味评价。结果表明,它们都具有硫磺样、热带水果样香味特征,阈值为18.5～30.7mg·kg-1。

The potassium hydroxide in the amino acid solution,followed by adding 38% formaldehyde,2mol/L of sodium hydrosulfide solution under 0℃,fully stirred and then allowed to naturally rise to room temperature overnight,were synthesized N-1,3,5-dihydrodithiazinyl acetic acid,2-（N-1,3,5-dihydrodithiazinyl）propanoic acid and 3-phenyl-2-（N-1,3,5-dihydrodithiazinyl）propanoic acid,yields were 77. 2%,73. 7% and 67. 1%. Structures of these compounds by IR,MS and 1H NMR testing techniques were characterized,and their fragrance was taken for a preliminary evaluation. The results showed that they all had sulfur-like,tropical fruit-like flavor characteristics,the threshold value of 18. 5～30. 7mg·kg-1.