燮理阴阳汤治疗围绝经期综合征的临床疗效

Clinical efficacy of Xieliyinyang decoction on perimenopause syndrome

目的探讨燮理阴阳汤治疗围绝经期综合征的临床疗效。方法选择我院门诊围绝经期综合征患者318例,随机分为治疗组212例,对照组106例。治疗组应用燮理阴阳汤1剂,po,bid;对照组应用更年安片4片,po,tid。两组疗程均为21 d。对治疗组和对照组患者治疗前后的临床症状进行评分,判断疗效。分别测定治疗组治疗前后患者血清中促卵泡生成素(FSH)和雌二醇(E_2)的浓度。结果总有效率治疗组为98.60%,对照组为91.50%,P<0.01。治疗组治疗前后血清中FSH浓度分别为(58.79±30.86)、(59.34±29.33)mIU·L^(-1),P>0.05;E_2质量浓度分别为(30.18±42.16)、(40.60±42.16)pg·L^(-1),P<0.05。结论燮理阴阳汤能有效提高血中E_2浓度,改善围绝经期综合征症状。

AIM To study clinical efficacy of Xieliyinyang decoction on perimenopause syndrome. METHODS A total of 318 patients with perimenopause syndrome were divided into 2 groups at random： the test group （212 patients, treated with a dose of Xieliyinyang decoction, po, bid for 21 d） and the control group （ 106 patients, treated with 4 geng- nian＇an tablets,po ,bid for 21 d）. Before and after treatment, patients in 2 groups were scored according to their clinical symptoms. Meanwhile, senan follicle-stimulating honnone（FSH） and estradiol （E2） of patients in the test group were ob- served respectively. RESULTS The clinical effective rate of the test group was 98.60%, and that of the control group was 91.50%, P 〈 0.01. Before and after treatment, serum FSH of patients in the test group was （58.79 ＋ 30.86） mIU＇L-t and （59.34 ＋ 29.33） mIU＇L-1 respectively, P 〉 0.05; serum E2 of patients in the test group was （30.18 ＋ 42.16） pg＇L-1 and （40.60＋42.16） pg＇L-1 respectively, P 〈0.05. CONCLUSION Xieliyinyang decoction could increase serum Eo level effectively and improve svndlome.