头孢曲松钠联合左氧氟沙星治疗肝硬化并自发性细菌性腹膜炎的疗效观察

Treatment of liver cirrhosis with spontaneous bacterial peritonitis by ceftriaxone sodium combined with levofloxacin

目的观察头孢曲松钠联合左氧氟沙星治疗肝硬化并自发性细菌性腹膜炎的疗效。方法将72例肝硬化并发自发性细菌性腹膜炎随机分为治疗组37例和对照组35例,治疗组给予头孢曲松钠2g,静脉注射,2次/d,左氧氟沙星注射液0.3 g,静滴,2次/d;对照组给予头孢哌酮/舒巴坦钠2g,静滴,2次/d。疗程14～21 d,观察两组治疗后的疗效。结果治疗组总有效率为89.19%,对照组总有效率为68.57%,治疗组疗效明显优于对照组(P<0.05)。结论头孢曲松钠联合左氧氟沙星治疗肝硬化并自发性细菌性腹膜炎疗效显著。

Objective To study the effects of the treatment of liver cirrhosis with spontaneous bacterial peritonitis by ceftriaxone combined with levofloxacin. Methods Seventy-two liver cirrhosis patients with spontaneous bacterial peritonitis were randomly divided into treatment group （37 patients） and control group （35 patients）. The treatment group received eeftriaxone 2 g plus levofloxacin 0. 3 g, the control group received cefoperazone/sulbactam 2 g intravenously two times, one per day. Patients were observed from 14 to 21 days after the treatment was administered. Results The total effective effect of the treatment group and the control group were 89. 19% and 68. 57% respectively. The efficiency of the treatment group was significantly higher than the control group （ P 〈 0. 05 ）. Conclusion The ceftriaxone sodium combined with levofloxacin had a significant effect for the treatment of liver cirrhosis with spontaneous bacterial peritonitis.