基于DPA识别基团的锌离子荧光传感器

Zinc Fluorescent Sensors with Receptors Derived from DPA

锌离子在生物体系中扮演着重要角色,其分析和检测在疾病诊断和医疗检测等方面具有重要价值。用于Zn2+检测的荧光传感器具有检测方便、灵敏度高等优点,引起了广泛关注。典型的荧光传感器通常是由识别基团和作为报告单元的荧光团通过间隔基团或直接连接而组成的。识别基团是荧光传感器的作用核心,在高选择性识别过程中起着至关重要的作用。自1996年第一次接在荧光素上以来,DPA(N,N-二(2-吡啶甲基)胺,di-2-picolylamine)基团在锌离子传感器的设计中得到了广泛应用。本文综述了近年来文献中报道的基于DPA识别基团的锌离子传感器,介绍了锌离子荧光传感器的合成方法与识别原理,最后简单介绍了锌离子传感器中其它几种常见的识别基团。

Zinc ion plays important roles in many biological systems.Its analysis and detection are highly valuable in clinical diagnosis and therapeutic monitoring.Fluoresecent zinc sensors have attracted extensive interest due to their simplicity and high sensitivity.A typical fluorescent sensor contains a receptor linked to a fluorophore directly or through a spacer,which translates the recognition event into the fluorescence signal.As the action centre of the sensor,the receptor unit plays an important role in the whole recognition process.Since its first incorporation to fluorescein in 1996,di-2-picolylamine（DPA） has been used as the most popular receptor to construct Zn2＋ sensors.In this review,we briefly summarized various kinds of zinc sensors with receptors derived from DPA,and discussed the synthesis and the sensing mechanisms of the sensors.In the last part of the paper,other receptors that might be incorporated into Zn2＋ sensors are also briefly introduced.