抗真菌药物的规范应用

Standardized application of antifungal agents

侵袭性真菌感染(IFI)最多发生于免疫受损或免疫功能低下的患者中,抗真菌治疗的效果直接关系到此类患者的基础疾病的疗效和长期存活,应重视抗真菌药物的规范应用。文章阐述了规范性应用抗真菌药物的概念,提倡依据不同危险因素的患者群推测可能的致病真菌,以诊断分层为基础,综合药物特性、区域性特点和价格效能比,足量、足疗程地使用抗真菌药物,并依据指南疗效评估标准评价治疗效果并调整用药。

Summary ： Invasive fungal infection （IFI） often occurs in the immunocompromised patients. The response of antifungal agents affects the outcome primary disease and the long term survival of patient, hence, the standardized application of antifungal agents should be addressed. Its concept was defined in the manuscript. Standardized dosage and proper course of treatment with antifungal agents should be given according to the probable pathogen in patients with different risk factors, that was based on the stratified diagnosis of IFI with consideration of epidemiology,characteristics and the ratio of price to efficacy of the agent. The application of antifungal agents might be modified according to the evaluation of response based on the Chinese antifungal guideline for patients with hematological malignancies.