胶原改性的生物活性玻璃/聚己内酯多孔骨修复材料的制备

Preparation of collagen modified bioactive glass/poly(ε-caprolactone) porous composites for bone tissue repairing

结合粒子沥滤-溶剂挥发法,制备以胶原作为孔壁修饰体的生物活性玻璃(BG)/聚己内酯(PCL)多孔骨修复复合材料。用SEM、FTIR、XRD、等离子体原子发射光谱仪和pH计等对材料的多孔及孔壁形貌、矿化活性、矿化溶液中离子浓度、pH值变化等进行了分析,采用比重法和称重法研究了胶原对多孔材料的孔隙率和吸水倍率的影响。结果表明:胶原蛋白成功的黏附到了多孔材料的孔壁,有效改善了BG/PCL复合材料的亲水性、矿化活性和降解性能,其孔隙率和吸水倍率分别高达96.400%±0.018%和13.65±1.65。

Bioactive glass（BG）/poly（ε-caprolactone）（PCL） porous composites modified by collagen for bone repairing were prepared by combining particulates-leaching and solvent-evaporation methods. The morphology of the porous materials and pore wall, mineralization activity, ionic concentration and variation of pH values were characterized by SEM, FTIR, XRD, plasma atomic emission spectroscope and pH meter. The effects of colllagen on the porosity and water absorption rate were characterized by traditional specific-gravity and weighing methods. The results indicate that collagen can be succesfully adhered onto the pore wall and the mineralization activity and degradability of BG/PCL are effectively improved. Porosity and water absorption rate are as high as 96. 400%± 0. 018% and 13.65±1.65, respectively.