ZnFe_2O_4-羧甲基壳聚糖磁性复合微球的制备及性能

Preparation and drug loading property of magnetic ZnFe_2O_4-carboxymethyl chitosan composite microspheres

采用溶胶-凝胶法制备出ZnFe2O4磁性纳米粒子。以水作溶剂对壳聚糖进行改性,得到羧甲基化壳聚糖(CMC)。在交联剂的作用下,用CMC包覆ZnFe2O4制备出ZnFe2O4-CMC磁性复合微球,并固载药物阿司匹林。经过XRD、IR、SEM、TEM、VSM、UV等手段对材料进行表征和性能研究。结果表明,磁性复合微球成球性好,平均直径为1～5μm,饱和磁化强度为10.99emu/g,24h内药物释放率为76.82%,载药率为0.801g/g,包封率为78.3%。复合微球性能优良,可作为一种新型的药物载体。

The magnetic ZnFe2 04 nanoparticles were prepared by sol- gel method, and the carboxymethyl chitosan （CMC） was obtained by modification of chitosan with water as the solvent. The ZnFe2O4 coated magnetic ZnFe2 04- CMC composite microspheres were prepared with the crosslinker, in which the aspirin has been loaded. The materials were characterized by XRD, IR, SEM, TEM, VSM, UV, et al. The results show that the magnetic composite microspheres are well- shaped with the average diameter being about 1 - 5 μm, the saturation magnetization being 10.99 emu/g, the dose of releasing drug being 76.82% in 24 h, the loading rate being 0. 801 g/g and the enveloping rate being 78. 3%. The performance of material is excellent, which may be used as a novel drug carrier.