乳腺导管内正常菌群的研究

Identification of normal flora in breast duct

目的研究乳腺导管内细菌的分布情况。方法对130例行双侧乳管镜检查的女性患者(260例乳房),根据体检、B超及乳管镜检查结果分为3组:完全正常组69例,乳腺导管扩张症组107例,积乳症组84例。对每例患者收集乳管冲洗液进行细菌培养。结果有20种细菌被检出,细菌检出率前3位为凝固酶阴性葡萄球菌、金黄色葡萄球菌、芽孢杆菌,且以前两种为主。乳管内多数以一种细菌生长为主,有时可为几种细菌共生长。积乳症组细菌检出率最高,与完全正常组比较差异有统计学意义;乳管扩张症组检出率次之,与完全正常组比较差异无统计学意义。结论乳管内细菌数量活动在101～103 CFU/mL之间。

Objective To study the distribution of flora in breast duct.Methods 130 cases of female patients（260 cases of breast）,accepting bilateral breast duct endoscopy,were divided into 3 groups according to physical examination,B-ultrasound inspection and breast duct endoscopy,including 69 cases were asymptomatic and results of all exams were normal,107 cases were with ductal ectasia and 84 cases were with galactostasis.Ductal lavage specimen was collected and underwent bacteria culture for each case.Results 20 species of bacteria were isolated.The top three species of detection rate were coagulase negative staphylococci,Staphylococcus aureus and Bacillus,and the former two were the main.Most ductal lavage specimen were positive with one one specie of bacteria.There was statistical difference of isolation frequency of bacteria between galactostasis group and the normal group,but no statistical difference between ductal ectasia group and normal group.Conclusion The quantity of ductal bacteria ranged from 101 CFU/mL to 103 CFU/mL.