期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

OCT4与肺癌

OCT4 and lung cancer
原文传递
导出
摘要 OCT4是全能性或多能性干细胞标志物，是维持胚胎十细胞多潜能性和自我更新不可或缺的转录因子。近年来研究发现OCT4的异常表达与肺癌的发生、发展、转移及预后密切相关。 OCT4,a totipotent or pluripotent stem cell marker,is an essential transcription factor to maintain the pluripotency and self-renewal of embryonic stem ceils. Recent studies found that the abnormal expression of OCT4 is closely related with the progression, metastasis and prognosis of lung cancer.
作者 李劳冬 莫碧文
机构地区 桂林医学院附属医院呼吸内科
出处 《国际呼吸杂志》 2011年第22期1724-1727,共4页 International Journal of Respiration
关键词 OCT4 肺癌 肿瘤干细胞 干细胞 OCT4 Lung cancer Cancer stem cells Stem cells
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献31

  • 1Jema[ A, Siegel R, Ward E,et al. Cancer statistics,2006. CA Cancer J Clin,2006,56:106- 130.
  • 2Lee J, Kim HK, Rho JY,et al. The human OCT 4 isoforms differ in their ability to confer self-renewal. J Biol Chem, 2006,281:33554 -33565.
  • 3Kotoula V, Papamichos SI, I.ambropoulos AF. Revisiting OCT4 expression in peripheral blnod mononuclear cells. Stem Cells, 2008,26 : 290- 291.
  • 4Wang X, Zhao Y, Xiao Z, et al. Alternative translation of OCT4 by an internal ribosome entry site and its novel function in stress response. Stem Cells, 2009,27 : 1265-1275.
  • 5Atlasi Y, Mowla SJ, Ziaee SA,et al. OCT4 spliced variants are ditterentially expressed in human pluripotent and nonpluripotent cells. Stem Cells, 2008,26:3068 -3074.
  • 6Suo G, Han J, Wang X, et al. Oct4 pseudogenes are transcribed in cancers. Biochem Biopbys Res Commun, 2005, 337:1047-1051.
  • 7Niwa H, Miyazaki J, Smith AG. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self- renewal of ES cells. Nat Genet, 2000,24 : 372-376.
  • 8Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotcnt stem cells from adult human fibroblasts by defined factors. Cell, 2007,131 : 861-872.
  • 9Yu J, Vodyanik MA, Smuga-Otto K, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science, 2007,318:1917-1920.
  • 10Heng JC, Feng B, Han J,et al. The nuclear receptor NrSa2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell, 2010,6 : 167-174.

二级参考文献37

  • 1郑必强,周瑾,耿沁,董强刚.人肺腺癌干细胞源自肺脏细支气管肺泡干细胞的初步研究[J].中国肺癌杂志,2008,11(6):759-764. 被引量：12
  • 2黄进肃,董强刚,包国良,韩宝惠.血液中微转移癌细胞对非小细胞肺癌预后的影响[J].中华肿瘤杂志,2004,26(5):294-296. 被引量：9
  • 3董强刚,韩宝惠,黄进肃,杨立民,黄建,赵春英,卢丽琴.176例非小细胞肺癌的EGFR基因突变分析[J].中华肿瘤杂志,2006,28(9):686-690. 被引量：53
  • 4Dong Q,Huang J,Zhou Y,et al.Hematogenous dissemination of lung cancer cells during surgery:quantitative detection by flow cytometry and prognostic significance.Lung Cancer,2002,37:293-301.
  • 5Kim CF,Jackson EL,Woolfenden AE,et al.Identification of bronchicalveolar stem ceils in normal lung and lung cancer.Cell,2005,121:823-835.
  • 6Kim CF.Paving the road for lung stem cell biology:bronchioalveolar stem cells and other putative distal lung stem cells.Am J Physiol Lung Cell Mol Physiol,2007,293:L1092-L1098.
  • 7Reya T,Mortison SJ,Clarke MF,et al.Stem cella,cancer,and cancer stem cells.Nature,2001,414:105-111.
  • 8Ho MM,Ng AV,Lain S,et al.Side population in human lung cancer cell lines and tumors is enriched with stem-like cancer cells.Cancer Res,2007,67:4827-4833.
  • 9Eramo A,Lotti F,Sette G,et al.Identification and expansion of the tumorigenic lung cancer stem cell population.Cell Death Differ,2008,15:504-514.
  • 10Chen YC,Hsu HS,Chen YW,et al.Oct-4 expression maintained cancer stem-like properties in lung cancer-derived CD133-possiive cells.PLoS One.2008.3:e2637.

共引文献47

国际呼吸杂志
2011年 第22期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部